Products related to MRNA:
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mRNA Vaccines
The formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the development of fully synthetic mRNA vaccines are discussed in this volume.The applications of the mRNA technology is covered, focusing on infectious diseases but also touching on other indications, such as immunotherapies and molecular therapies.Potent and long-lasting immune responses observed in animal models, encouraging data from early human clinical studies, together with the success of two mRNA-based COVID-19 vaccines support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches.Consequently, the development progress of the technology, particularly on production, capabilities, and clinical development is reviewed.Topics on safety, regulatory issues, and possible challenges to the mRNA vaccination approach round off this book.Thanks to their high potency, the prospect for generic,low-cost manufacturing processes, and entirely synthetic nature, the future for mRNA vaccines is highly promising.Importantly, mRNA vaccines have the potential to minimize the time between pathogen identification and vaccine release with a huge impact on public health.As the mRNA-based vaccination technology has been progressing rapidly, the book is intended to be an end-to-end review series, covering everything from basic RNA biology and preclinical studies to the manufacturing strategy, clinical development and regulatory approval.It provides established RNA researchers and developers with updates on the latest advancements in the field and allows for a quick but comprehensive overview of this transformative technology, its application, and future potential.
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Trends in mRNA Vaccine Research
The authoritative guide to the revolutionary concept behind the successful Covid-19 vaccines In Trends in mRNA Vaccine Research, a team of distinguished researchers delivers a practical and up-to-date discussion of the biochemical and biomedical foundations of mRNA vaccines.They also explore the manufacturing conditions required for successful vaccine development and review recent progress in a variety of medical fields, including vaccines against pathogens like SARS-CoV-2, HIV, plasmodium, Mycobacterium tuberculosis, as well as anticancer vaccines.Volume highlights include: A historical overview of mRNA vaccine developmentImmune responses to modified or unmodified mRNA vaccinesA description of the different mRNA vaccine platformsLatest data on current mRNA vaccine developments against infectious diseases and cancer Perfect for medicinal chemists, immunologists, and epidemiologists, Trends in mRNA Vaccine Research will also benefit researchers and scientists working in the pharmaceutical industry, as well as cancer researchers with an interest in vaccine development.
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Portfolio Management : Delivering on Strategy
Portfolio management is becoming the ‘must have’ for organizations to prosper and survive in this decade and beyond.No longer can the organizational focus be one of following best and repeatable practices as resource limitations mean only those programs, projects, and operational work that add business value can and should be pursued.Executives are focusing on strategic ability and managing complexity, which can only be done through a disciplined portfolio process in ensuring the best mix of programs, projects, and operational work is under way.In turn, the portfolio is constantly in flux as difficult decisions are made if a project, for example, is no longer contributing to business value and providing benefits and should be terminated to reallocate resources to one of higher priority.Commitment to this difficult approach is necessary at all levels, and communication is required so everyone knows how their work contributes to the organization’s strategic goals and objectives. Portfolio Management: Delivering on Strategy, Second Edition focuses on the benefits of portfolio management to the organization.Its goal is to provide senior executives a view on how portfolio management can deliver organizational strategy.The emphasis is on the specific aspects within the portfolio management discipline and how each aspect should be managed from a business perspective and not necessarily from a portfolio management perspective.Highlights of the book include:Agile portfolio management Delivering organizational value Portfolio management and uncertainty Portfolio governance Marketing a portfolio Portfolio management success Starting with a review of the project portfolio concept and its development, this book is a reference for executives and practitioners in the field, as well as a students and researchers studying portfolio management.
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Applied Fundamentals in Finance : Portfolio Management and Investments
This textbook provides a comprehensive introduction to portfolio management and investments.Focusing on four core areas – portfolio management, equities, bonds, and derivatives – it is primarily intended for undergraduate and graduate students alike.However, it will also benefit practitioners working in the fields of financial analysis and portfolio management and professionals who aspire to such professional activities in the financial industry.To ensure its high practical relevance, the book includes a host of case studies and examples from real-world practice, mainly from the German and Swiss financial markets.Additionally, the book shows how to implement the models in Microsoft Excel.
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Is the mRNA vaccine safe?
Yes, the mRNA vaccines have been shown to be safe and effective in clinical trials and real-world use. The vaccines have undergone rigorous testing and have been authorized for emergency use by regulatory agencies such as the FDA and the European Medicines Agency. Millions of people have received the mRNA vaccines with only rare and mostly mild side effects reported. The benefits of vaccination in preventing severe illness and death from COVID-19 far outweigh the potential risks.
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How does mRNA maturation occur?
mRNA maturation occurs through a process called RNA processing. This process involves several steps, including capping, splicing, and polyadenylation. First, a 5' cap is added to the beginning of the mRNA molecule to protect it and help it bind to the ribosome. Then, introns (non-coding regions) are removed through a process called splicing, and the remaining exons (coding regions) are joined together. Finally, a poly-A tail is added to the end of the mRNA molecule to help stabilize it and regulate its translation. These steps ensure that the mRNA molecule is properly processed and ready for translation into protein.
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What is mRNA in food?
mRNA in food refers to the presence of messenger RNA molecules that are naturally occurring in the cells of plants and animals that we consume as food. mRNA is a type of RNA that carries genetic information from the DNA in a cell's nucleus to the ribosomes, where it is used to produce proteins. In the context of food, mRNA is not a cause for concern as it is a normal component of the cells in the food we eat and is broken down during digestion without any known harmful effects.
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Is mRNA the same as RNA?
mRNA (messenger RNA) is a type of RNA (ribonucleic acid). RNA is a broad category that includes several types of molecules involved in various cellular processes, including mRNA, tRNA (transfer RNA), and rRNA (ribosomal RNA). mRNA specifically carries the genetic information from the DNA in the cell's nucleus to the ribosomes, where it is used as a template for protein synthesis. Therefore, while mRNA is a type of RNA, not all RNA molecules are mRNA.
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Behavioral Finance and Your Portfolio : A Navigation Guide for Building Wealth
Become a more strategic and successful investor by identifying the biases impacting your decision making. In Behavioral Finance and Your Portfolio, acclaimed investment advisor and author Michael M.Pompian delivers an insightful and thorough guide to countering the negative effect of cognitive and behavioral biases on your financial decisions.You’ll learn about the “Big Five” behavioral biases and how they’re reducing your returns and leading to unwanted and unnecessary costs in your portfolio. Designed for investors who are serious about maximizing their gains, in this book you’ll discover how to: ?Take control of your decision-making—even when challenging markets push greed and fear to intolerable levels ?Reflect on how to make investment decisions using data-backed and substantiated information instead of emotion and bias ?Counter deep-seated biases like loss aversion, hindsight and overconfidence with self-awareness and hard facts ?Identify your personal investment psychology profile, which you can use to inform your future financial decision making Behavioral Finance and Your Portfolio was created for individual investors, but will also earn a place in the libraries of financial advisors, planners and portfolio managers who are determined to counteract the less principled and data-driven aspects of their decision making.
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Portfolio Selection : Efficient Diversification of Investments
This is a classic book, representing the first major breakthrough in the field of modern financial theory.In effect, it created the mathematics of portfolio selection in a model which has turned out to be the indispensable building block from which the theory of the demand for risky securities is constructed.
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Digital Assets : A Portfolio Perspective
From the perspective of an investor, digital assets are an alternative class of assets.They have several features that differentiate them from traditional investments.This makes them well-suited for a diversified portfolio.The question is how to accommodate them in such a portfolio, how to manage their potential and risk, and how to evaluate them.This short book explains how to include digital assets is a diversified portfolio.It focuses on their differentiating use cases, their idiosyncracies, and how they relate to other types of investment.This is a volume for practitioners and students in finance, asset management, or portfolio construction.
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Digital Assets : A Portfolio Perspective
From the perspective of an investor, digital assets are an alternative class of assets.They have several features that differentiate them from traditional investments.This makes them well-suited for a diversified portfolio.The question is how to accommodate them in such a portfolio, how to manage their potential and risk, and how to evaluate them.This short book explains how to include digital assets is a diversified portfolio.It focuses on their differentiating use cases, their idiosyncracies, and how they relate to other types of investment.This is a volume for practitioners and students in finance, asset management, or portfolio construction.
Price: 49.99 £ | Shipping*: 0.00 £
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How can DNA be translated into mRNA?
DNA is transcribed into mRNA through a process called transcription. During transcription, the DNA double helix unwinds and an enzyme called RNA polymerase binds to a specific region of the DNA called the promoter. The RNA polymerase then reads the DNA sequence and synthesizes a complementary mRNA strand by adding nucleotides one by one. This process continues until the RNA polymerase reaches a termination signal, at which point the newly synthesized mRNA is released. This mRNA molecule can then be translated into a protein by the ribosomes.
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How can one transcribe DNA into mRNA?
Transcribing DNA into mRNA involves the process of transcription, which takes place in the nucleus of a cell. During transcription, the enzyme RNA polymerase binds to a specific region of the DNA called the promoter and unwinds the DNA double helix. It then uses one strand of the DNA as a template to synthesize a complementary mRNA strand by adding nucleotides according to the base-pairing rules (A with U, T with A, C with G, and G with C). Once the mRNA strand is synthesized, it is processed and then transported out of the nucleus into the cytoplasm for translation into a protein.
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How long is the lifespan of mRNA?
The lifespan of mRNA can vary depending on the specific mRNA molecule and the cellular conditions. In general, the average lifespan of mRNA in a eukaryotic cell is around 10 hours, but some mRNA molecules can be very short-lived, lasting only a few minutes, while others can be more stable and persist for several days. The stability of mRNA is influenced by factors such as the presence of specific sequences in the mRNA molecule, the activity of RNA-binding proteins, and the cellular environment.
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How does the maturation of mRNA occur?
The maturation of mRNA involves several steps. First, the pre-mRNA is processed by removing the non-coding regions, called introns, and joining the coding regions, called exons, through a process called splicing. Then, a 5' cap and a 3' poly-A tail are added to the mRNA to protect it from degradation and facilitate its export from the nucleus. Finally, the mature mRNA is ready to be translated into a protein by the ribosomes in the cytoplasm. This process ensures that only the necessary coding information is present in the mature mRNA for protein synthesis.
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